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Finally, we used multi-way sensitivity analyses to explore combined effects to represent the general female population of Tijuana and Ciudad Juarez.
To explore combined antitumor effects of dasatinib with cytotoxic agents, combined treatments of dasatinib (0.1 μM) with the indicated concentrations of Eto were examined in the basal B cell lines.
The well-designed genomics projects in each domain have helped investigators to generate massive amount of genetic data, presenting new opportunities to interrogate the information revealed in each single domain and to explore combined analyses across platforms.
Although there are RASSLs described previously for each of the three primary Gα signaling pathways (Gs, Gi, and Gq), the hFFA2-RASSL described in the present work is the first RASSL to selectively coactivate two of these pathways, and thus may represent a novel means to explore combined Gi/Gq activation after its expression in vitro or in vivo.
Exploitation of this phenomena, in addition to the value of functional redundancy in drive mechanisms, could provide a valuable practical incentive to explore combined drive systems experimentally.
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To further explore combined correlations (i.e., shared variance) between the variables and degree of elevated HAQ, variables that correlated significantly with elevated HAQ were put into multiple linear regression analyses (using a stepwise forward procedure where at each step the variable which added most to the model was added until no more variable could be added with p < 0.05).
Also, explore combining one-way flights on two airlines to create a roundtrip itinerary.
A combined burden and intervention opportunity score (CBIO) was constructed to explore the combined effect of relative disease burden and intervention opportunity.
To explore the combined effect of both recipient and donor genotypes, the following combinations were made for CYP3A5: C1, donor and recipient are CYP3A5*1 non-carriers; C2, recipient is CYP3A5*1 carrier and donor is non-carrier; C3, recipient is CYP3A5*1 non-carrier and donor is carrier; and C4, both donor and recipient are CYP3A5*1 carriers.
The selectivity profile of the best performing derivatives belonging to series 2 was further explored combining modeling studies and additional assays in a panel of human cell lines and other kinases.
The results obtained were used, to explore the combined effects of changing pore pressure on slippage and absolute permeability.
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