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We tested the hypothesis that alterations to non-parenchymal cell activation are sufficient to explain altered regeneration in these disease phenotypes.

We therefore tested whether alterations in hepatocyte response to non-parenchymal cells are sufficient to explain altered regeneration in these same disease phenotypes by changing parameters related to hepatocyte response to non-parenchymal cells (14 out of 33 parameters, Additional file 20: Table S3).

We found that for NASH, ASH, and cirrhosis, alterations in hepatocyte response to non-parenchymal cells was also sufficient to explain altered regeneration in these disease phenotypes (Additional file 21: Figure S17A-C).

This result indicates that altered non-parenchymal cell activation is sufficient to explain altered regeneration in these disease phenotypes.

Neither patient had significant abnormalities in their liver enzymes or serum albumin to explain altered phenytoin binding or clearance.

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However, other binding proteins, such as thymine-DNA glycosylase and ecotropic viral intergration site 1, can adhere to sites within the DNMT3A catalytic domain and may explain altered mutant DNMT3A activity (Li et al., 2007; Senyuk et al., 2011).

As the calcium gradient is thought to represent an important physiological mechanism regulating keratinocyte maturation, defects in this system could easily explain altered proliferation and differentiation of psoriatic keratinocytes.

If impairment of microvascular autoregulation does indeed exist in other septic organs, it may help explain altered gene expression in the septic heart [ 33], as it responds to local hypoxia.

Climate change may partly explain altered species-habitat associations [6].

These data may also explain altered social decision-making in clinical groups.

There was no evidence of a significant change in diet quality (C∶N ratio of gut contents) for any of the species that could explain altered discrimination.

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