Gait analysis, radiographs, ultrasound and serum insulin and glucose concentrations were performed prior to the exercise trial and at each time point.
To our knowledge, the CARE Trial is the largest exercise trial to date to examine moderators of the exercise response in cancer patients, and the first to examine moderators of different types and doses of exercise.
In addition to the acute exercise trial, a portion of the 65-86 year old sedentary subjects underwent 12 weeks of twice-weekly aerobic exercise training on a Monark Cardio Care 827E cycle ergometer.
We hypothesised that cancer patients willing to participate in an exercise trial would be dissatisfied when allocated to usual care only.
It was not known whether the positive effects of exercise for knee OA could be extrapolated to hip OA because exercise trials mostly included knee OA patients.
Also, with unpaired t tests, we compared between sexes the relative change from baseline during exercise trials to that in C trials when either sex showed a significant difference from C after exercise.
"We weren't able to find many exercise trials, which adds to the limitations of the findings.
The remaining three studies reported significant differences from baseline to post-exercise within the exercise trial [16, 66] and between [16, 50, 66] exercise and control conditions.
Ad libitum energy intake was not different between trials, resulting in a negative energy balance in exercise trials relative to control after accounting for differences in energy expenditure (control: 9774 ± 2694 kJ; fasted exercise: 6481 ± 2318 kJ; postprandial exercise: 6017 ± 3050 kJ).
Moreover, it may also be of interest to evaluate the impact of exercise trials tailored for members of the general public.
Forty-five adolescents (13.3 ± 0.3 years old), undertook a bout of exercise (ten repeats of level one of the multi-stage fitness test, 30 s rest between repeats; exercise trial) or continued to rest (resting trial).
