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While the constructs used in the experiment are widely accepted as generally implicating left versus right activity, neither the RFFT nor the COWAT can be said to exclusively activate a given hemisphere.
Therefore, to exclusively activate Erk2 without affecting other signaling pathways, K562 sensitive cells were stably transfected with an exogenous constitutively active MEK1.
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First, they need to selectively and exclusively activate one gene of the family at a time.
While ERK5 is believed to be exclusively activated by MEK5-dependent phosphorylation events, MEKK2/3 and MEK5 are sensitive to a variety of regulatory interactions and signaling pathway inputs [ 48, 49].
Some regions within the so-called pain neuromatrix exhibit significantly correlated activity with sensory or emotional descriptions of the painful experience, suggesting that they have a significant role in pain generation but no brain region has been shown to be exclusively activated during pain experiences.
Our data confirmed that the antioxidant ethoxyquin (EQ) and the isothiolcyanate sulfurophane (SFP) exclusively activate the antioxidant response element (ARE), and thus represent monofunctional inducers.
In Sox2- Cre: Errβ lox / lox null mice, DY131 would exclusively activate Errγ and that this would result in alterations in HPA axis function (e.g. Crh expression or corticosterone levels).
It is suggested that high CF101 doses may activate the A2A receptor resulting in IL-12 downregulation, whereas low doses, as was used in this study, exclusively activate the A3AR and will results in IL-12 upregulation and potentiation of NK cell activity.
For instance, it has been observed using a combination of glutamate binding-deficient and G protein coupling-deficient receptors that the mGlu1 receptor triggers Gq-coupled signalling through cis- and trans-activation, while Gi/o and Gs are exclusively activated through cis-activation (Tateyama and Kubo 2011).
Here, we show tunable rescue of motor function in a mouse model of PD, following transplantation of human midbrain dopaminergic (mDA) neurons differentiated from hPSCs engineered to express DREADDs (designer receptors exclusively activated by designer drug).
Ribosomal S6 kinases (RSKs) constitute a family of serine/threonine kinases that in response to various stimuli are almost exclusively activated by extracellular signal-regulated kinases 1/2 (ERK1/2).
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