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However, the Kaplan-Meier survival curves intersected at 274 days (Figure 5B), suggesting that tumors were ultimately able to "escape" suppression mediated by dominant negative PEA3.
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Thus, degradation by calpains is a novel mechanism for downregulation of NORE1A and RASSF1A proteins and might be the mechanism allowing cancer cells to escape growth suppression.
We can think of three scenarios in which viral densities are suppressed to the point where coinfection is unlikely and where two or more mutations are needed to escape from suppression.
Ovariole number is a recognized marker of reproductive potential in honey bees (Makert et al. 2006; Tanaka and Hartfelder 2004) demonstrating that workers with the most ovarioles and thus greatest reproductive potential are most likely to escape ovary suppression.
While not mutually exclusive, these data highlight the important double-edged role of IL-2 both in enabling Tregs to suppress and target cells to escape Treg-suppression.
Theatrical performances escaped suppression because they funded these charitable organizations.
They saw Fiji as a place to escape exploitation and suppression suffered in India.
Cells have to escape from this suppression to organize into spots or rods.
We agree that it would be desirable to provide more insights into the molecular mechanisms that allow CD4+ T cells to escape Treg-mediated suppression in vivo.
Integrin-associated death is a driving force behind prostate tumorigenesis, as cells attempt to escape this by suppression of integrin expression.
While a few specific transcripts are known to escape this translational suppression (Spriggs et al., 2010), the general link between transcriptional and translational changes during apoptosis is not well understood.
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