Upregulation of XO is reported in experimental models of heart failure and in human end-stage failing myocardium and its inhibition is reported to enhance mechanical efficiency and improve cardiac remodeling [84,85].
Numerous metals (Fe, Mn, Ni, Co, Zn, Ag, Cr) under various forms (salt of reduced metal, solid oxide, deposited metal on support) were reported to enhance the efficiency of ozone towards the removal (or the conversion) of different organic compounds in aqueous solution.
Two promising bioflavonoids luteolin and apigenin were reported to enhance reprogramming efficiency in mouse embryonic fibroblast (MEF).
Mutations in the nucleoprotein gene reported to enhance replication efficiency, virulence, and transmission (3 ) were absent in the isolate.
MDSC accumulation at distant metastatic sites, which contributes to the establishment of a pre-metastatic niche, has also been reported to enhance metastatic efficiency [ 14].
Notably, luteolin and apigenin are reported to enhance reprogramming efficiency through the upregulation of E-cadherin, which could replace Oct-4 during iPSC generation [ 8].
Since protamine sulphate was reported to enhance transfection efficiency of cationic lipid DNA complexes [ 33], it was added in increasing concentrations to 1 μg of plasmid DNA prior to the addition of the lipids at all the previously analyzed lipid to DNA ratios.
In some studies, ESAs were reported to enhance the efficiency of tumour-ablative therapy (Silver and Piver, 1999; Mittelman et al, 2001; Thews et al, 2001; Golab et al, 2002; Pinel et al, 2004; Sigounas et al, 2004; Ning et al, 2005) and induce tumour regression (Mittelman et al, 2001).
VIP was also reported to enhance the suppressive efficiency of Tregs on a per cell basis.
Electroporation has been reported to enhance the transfection efficiency of plasmid DNA delivered in vivo by intramuscular injection [ 10].
An electronic safety reporting (ESR) module was developed and integrated into a home-grown web-based clinical trial management system (CTMS) to enhance the efficiency, completeness and consistency of reporting and reviewing serious adverse events, monitoring safety, and submitting safety reports to regulatory authorities for a large multicenter clinical trial.
