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For example, using an in vitro mutagenesis screen Bradeen et al. [ 114] determined that combination therapies of dasatinib plus imatinib or dasatinib plus nilotinib were able to eliminate the development of all but one acquired mutation in a CML cell line model.
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Measures taken to eliminate the development and spread of many infectious diseases gradually resulted in a steady decline in mortality [ 20, 21].
Dietary interventions that reduce the inflammatory response could help eliminate the development of pain in chronic pain syndromes such as CDH.
Drug-eluting stents (DES) promised to reduce the clinical and economic cost of failed bare metal stents (BMS) by locally delivering a therapeutic agent to the injured artery, reducing or eliminating the development of neointimal hyperplasia and reducing the need for repeat interventions to re-open the obstructed artery.
Sorting and disposing of visibly moldy or damaged kernels before storage is an effective method for reducing but not eliminating the development of aflatoxins (Fandohan et al. 2005a; Turner et al. 2005).
Adult rather than immature rabbits were used to eliminate the factors of growth and development which may affect the accuracy of the study.
Conclusions: Among the most urgent avenues of research is the need for prospective studies to eliminate the possibilities of reverse causality, and development of new LINE-1 assays that capture both class of LINE-1 element and copy number.
The major aims of treatment for patients with type 1 or type 2 diabetes mellitus are to provide a level of glycemic control similar to that of nondiabetic individuals, to eliminate or delay the development of microvascular/macrovascular complications, and to minimize debilitating episodes of hypoglycemia and thus improve quality of life (QOL).
Potential beneficial uses of such "gene drives" include reprogramming mosquito genomes to eliminate malaria, reversing the development of pesticide and herbicide resistance, and locally eradicating invasive species.
28 That initial "Call to Action" led to the development of national plans to eliminate cholera in Haiti and the Dominican Republic, as well as an International Coalition to Eliminate Cholera in Hispaniola.
This will require development of more efficient ways to deliver siRNAs to cells or the development of new technologies to eliminate genes from cells all together (i.e., using the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system).
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