However, these studies largely imply that the miRNA resides within its host cell to elicit an effect [39].
The variable effects of ATP are also reflected in the sensitivity of cells to ATP, as different cell types require different concentrations of extracellular ATP to elicit an effect.
We supposed that the concentration of rituximab in ascites by intravenous infusion was not sufficient to elicit an effect.
There are a large number of studies where extremely high doses (mg/L) of pharmaceuticals have been administered, or are required, to elicit an effect.
This might be surprising given that as a signaling molecule ROL-3 is expected to elicit an effect within the major hypodermis where is it expressed.
While ASCs isolated from the abdomen of obese subjects demonstrated an increase in leptin expression, the cells failed to elicit an effect on breast cancer cell proliferation or tumor growth.
29 Since only a small amount is need to elicit an effect and the minimum amount that can be purchased is 1 g, users will continue to present themselves to A&E departments across the country.
Once a process is developed and transferred to commercial scale, generally, the scope changes from inducing process variability in order to elicit an effect to monitoring the normal variability in the process and establishing/maintaining process control.
Previous work showed that at least 10 100 nM PGE2 is required to elicit an effect on MMP up-regulation even in monocytes co-stimulated with other agonists (Corcoran et al., 1992; Shankavaram et al., 2001; Khan et al., 2004).
To elicit an effect in a biosystem, a chemical must reach the site of action, frequently located far away from the points of entry, which, for higher organisms, are typically the gastrointestinal and pulmonary tracts, skin, mucosa, and cornea.
The model of CA is based on the assumption that chemicals act via a similar mechanism to elicit an effect, such that one chemical acts as a dilution of the other and can be substituted at a constant proportion for the other.
