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It also produces increased diastolic SR Ca2 + leak with some prolonged Ca2 + sparks that at times become "metastable" and fail to efficiently terminate.
Thus, lack of an ISG43-encoded function might be responsible for the inability to efficiently terminate IFN-α-induced transcription in a subset of BL cells.
We conclude, therefore, that the inability to efficiently terminate IFN-α-induced signaling in a subset of BLs is due to insufficient expression of UBP43.
This regulatory mechanism has been proposed to function in synergy with resynthesised IκBα to efficiently terminate NF-κB responses (Saccani et al, 2004).
In this study, we show that Grc3 is a polynucleotide kinase, is present on rDNA and that its inactivation reduces the efficiency of termination by Pol I. We propose that Grc3 kinase activity is required to maintain the phosphorylated status of the downstream Rnt1 cleavage product, which in turn allows the torpedo activity of Rat1 to efficiently terminate Pol I transcription.
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Thus, MuHV-4 has evolved to encode a protein that, in a manner equivalent to cellular SOCS1 (Ryo et al, 2003), efficiently terminates the NF-κB response.
To satisfy the signal integrity requirements the driver strength is dynamically calibrated and the input/output port is efficiently terminated by on-die resistors.
The package has been tested on a variety of data sets and it has performed very efficiently, terminating in an overall number of active set changes over subranges of data that is only proportional to the number of data.
My response agreed with the thrust of Resmovits's post and agreed that bad teachers should be efficiently terminated.
We confirmed that ADH1t efficiently terminates the HMS2 transcript and that there are no detectable transcripts over the HMS2 3′ region.
Thus, the transcription of both genes is probably efficiently terminated in the IGS1 and/or genes are compartmentalized in cell nucleus (discussed further below).
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