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ESCs incorporated at a low percentage to supply sarcolemma-dystrophin and to effect corrections.
In mdx chimeras, iPSC-dystrophin was supplied to the muscle sarcolemma to effect corrections at morphological and functional levels.
Intriguingly, iPSCs (and ESCs, [35]) appeared to effect corrections in fat, which does not express dystrophin but does express utrophin.
To determine if dystrophin from the ESCs is required to effect corrections, we derived LacZ-marked ESC clones from mdx mice (Table 4).
We show that the iPSCs supply dystrophin to the sarcolemma to effect corrections in the skeletal muscle of mdx but not mdx∶utrophin.
Similar(55)
Calibration with respect to stem effect correction should therefore be performed for every investigated beam quality when using plastic scintillator detectors.
It is thus evidenced that the DFEI method is indeed a very efficient method used to conduct anharmonic effect corrections beyond QHA.
(6) involving the empirical compaction factor was then applied to effect this correction.
ESCs incorporated but failed to supply dystrophin and did not effect corrections [35].
Therefore, we decided not to use batch effect correction such as ComBat [ 85] because we observed that this can introduce bias to the data.
To date, little attention has been given to issues related to normalization and batch effect correction for this kind of data.
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