Sentence examples for to disrupted development from inspiring English sources

Mice overexpressing Fra-2 under the control of a cytomegalovirus promoter were reported to display ocular malformations due to disrupted development of anterior eye structures [ 14].

The loss of Isl1 expression is thereby very likely linked to Shox2 deficiency and does not constitute an indirect effect due to disrupted development of SAN tissue in knockout embryos.

It therefore seems that either developmental toxicity may be unrelated to AChE inhibition, or that even a brief period of AChE inhibition is sufficient to disrupt development [ 42].

Phthalate esters represent a class of environmental endocrine-active chemicals known to disrupt development of the male reproductive tract by decreasing testosterone production in the fetal rat.

The sex differences in 5HT synaptic proteins (Aldridge et al. 2004) and in the effects seen here in the plus maze point to the potential mechanisms underlying the ability of CPF to disrupt development and function of 5HT systems.

The N-terminal region of Spt5 (NSpt5: lacking the repeats phosphorylated by P-TEFb) acts in a dominant manner to disrupt development when expressed in zebrafish embryos 37. This variant impairs the repressive function of Spt5 in vitro and leads to de-repression of hsp70 in the absence of heat shock in vivo 37.

To gain more insight into the mechanisms underlying the ability of Mef2ca 4–5–6 to disrupt development, the expression levels of genes encoding transcription factors and signaling molecules that are involved in early patterning of the embryo were screened by semi-quantitative RT-PCR.

A previous study from our group showed that significant pulmonary elevations of adenosine in ADA-deficient mice lead to inflammation and disrupted development (6).

The 'hypomentalistic brain', typical for autism, is according to them caused by disrupted development resulting in a shift towards the 'mechanistic brain', while 'hypermentalistic' cognition, typical for schizophrenia, is caused by a shift towards the 'mentalistic brain'.

They demonstrate that the symptoms are associated with disrupted development of cranial nerves that are important for feeding and swallowing.

While it is important to continue to identify those environmental chemicals that disrupt development leading to birth defects, there must be an increased effort to develop criteria and assays that will capture the latent effects on long term development reflected by the DOHaD paradigm.