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Over the years, a large number of compounds with unrelated chemical structures have been reported to display affinity for σ receptors (Fig. 1).
Here, three Ab-functionalized SEPs, comprising gold octahedra as plasmonic units, are simultaneously retained at the cancer cell membrane, while only one is found to display affinity toward membrane receptors on the healthy cells.
Both ergotamine and dihydroergotamine (DHE) share structural similarities with serotonin, dopamine and (nor)adrenaline, and have been shown: (i) to display affinity for a wide variety of receptors including serotonin 5-HT1/2, dopamine D2-like and α1/α2-adrenoceptors [1]; and (ii) to be effective in the acute treatment of migraine [2].
In the large 14-3-3-phosphoproteomics 14-3-3-phosphoproteomics 14-3-3-phosphoproteomics 14-3-3-phosphoproteomicsinity for binding to 14-3-3 [ 1– 13].
There are now >2000 phosphoproteins that have been found to display affinity for 14-3-3 14-3-3 14-3-3ghput proteomins experiments (Jin et al., 2004; Nishioka et al., 2012; Pozuelo Rubio et al., 2004).
Wank (1995) had already demonstrated that a sulfated tyrosine in position 27 of CCK-33 is essential for CCK and its derivatives to display affinity for either CCK1 or CCK2 receptors.
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The purpose of this study was to identify and characterize Escherichia coli proteins which display affinity towards both Immobilized Metal Affinity Chromatography (IMAC) and Hydrophobic Interaction Chromatography (HIC).
PHD domains in other proteins also display affinity for methylated histones, such as PHF8, which binds to H3K4-me3 in rDNA [57].
Herpes simplex viruses (HSVs) display affinity for cell-surface heparan sulfate proteoglycans with biological relevance in virus entry.
Several of these domains, including DBL5ε, have, to some extent, displayed affinity for CSA in vitro [12], [13], [14], [15] [16].
Substituted norbenzomorphans are known to display high affinity and selectivity for the two sigma receptor (σR) subtypes.
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