This way TRF2 may directly stabilize the t-loop to sequester the 3' end from damage signaling and prevent subsequent recombination steps that would result in loss of telomeric DNA from chromosomes.
Indeed, OPA1 co-immunoprecipates with ATP synthase and both are retrieved in high-order crosslinked complexes, where OPA1 could directly stabilize ATP synthase.
Of the 18 amino acid substitutions introduced into parental NpR3784g (Supplementary Fig. 7e), F25C, Y27F, H87Y, N99I, and N117H are located within 3.6 Å of the chromophore and either directly stabilize it or provide for it favorable accommodation.
However, we found that, unlike jasplakinolide or phallacidin, cucurbitacin I does not directly stabilize actin filaments.
This is consistent with the observation that cucurbitacin I does not directly stabilize actin because actin is highly conserved between Dictyostelium and mammalian cells.
While one report provides evidence that cucurbitacin E may directly stabilize existing actin filaments in vitro [20], it is far from clear if this alone accounts for the full extent of dramatic actions of cucurbitacins on the actin cytoskeleton in the cell.
However, it remains possible that Sdf1 may not directly stabilize protrusions.
In addition, it has been found that CSA can directly stabilize podocyte actin cytoskeleton [ 93].
