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In addition to directly causing pain, it can also impair an individual's sleep, lower mood, and have a negative impact on daily activities, resulting in poor quality of life (2, 3).
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While long-distance running, for instance, doesn't seem to directly cause arthritis in most people's knees, it may speed the condition once it starts, Dr. Parks says.
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Recently, mutations that specifically alter the assembly or stability of microtubules have been found to directly cause neurodevelopmental defects or neurodegeneration in vertebrates.
While TRA did lead to substantial reductions in post-MD REM sleep (Fig. 1), this effect is unlikely to directly cause impairments in ocular dominance plasticity for the following reasons.
Validated tagSNPs are highly unlikely to directly cause CRC.
Building dampness itself is unlikely to directly cause adverse health effects.
ROS were reported to directly cause somatic cell mutagenesis and thereby promote cancer.
IL-9 also appears to directly cause the production of TGF β in antigen-presenting cells.
In addition, the lysosomal dysfunction caused by ATP13A2 mutations has been shown to directly cause α-synuclein accumulation [ 77 ▪, 78 ▪▪].
The significance of these mtDNA variants remains unclear but they would not be predicted to directly cause COX deficiency.
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