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While providing the ability to magnetically enhance delivery rates, ferrogels have not been able to produce the various types of regulated delivery profiles likely needed to direct complex biological processes.
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Interestingly, NP-1 has been shown to form direct complexes with VEGFR1 that result in decreased VEGF binding to NP-1 and VEGFR1, but the function of this interaction remains unclear [ 10].
Degradable materials are promising tools to understand and direct complex biological systems and cell behaviors, such as cell adhesion and spreading, migration, differentiation, proliferation, and apoptosis.
The functions of Odin in CRC are yet unknown and we have so far failed to see a direct complex formation of Odin and EphA8 in SW620 cells (data not shown).
Particularly fascinating are the many objects that point to direct and complex interactions between nomadic peoples and China.
When this had been denied by chief of staff Franz Halder, he had arranged the formation of an extra Army Corps headquarters to direct the complex strategic situation of simultaneously fighting the Allies and advancing into the Fortress Holland over the Moerdijk bridges.
Conversely, EGFP-tagged VVCA alone failed to induce actin assembly on microtubules, since in the absence of a targeting domain it was unable to direct Arp2/3 complex activation to the microtubule surface (Figure S1C).
Both the association of non-homologous centromeres and the formation of the telomere bouquet seem to direct the complex choreography of the homologue pairing process (Klutstein and Cooper 2014; Obeso et al. 2014; Scherthan 2001).
Redistribution of cytoplasmic PAK4 to membrane lamellipodea precedes its direct complexing to αv β5-integrin but not to β1-integrin (FN receptor) upon VN adhesion.
Although epigenetics may direct complex effects including changes in higher-order chromatin structure, DNA methylation differences are at least currently understood to control gene expression.
On the other hand, he did not believe central decision-makers had the ability to direct an infinitely complex and changing world.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com