In our continuous effort to develop new ligustrazine derivatives with neuroprotective effects, we attempted the synthesis of several ligustrazine-vanillic acid amide derivatives and screened their protective effect on the injured PC12 cells damaged by CoCl2.
As a part of our ongoing studies in developing new derivatives as antimicrobial agents we describe the synthesis of novel substituted 5-benzylideno-2-adamantylthiazol[3,2-b][1,2,4]triazol-6 5H ones.The twenty-five newly synthesized compounds were tested for their antimicrobial and antifungal activity.
Herein, we provide an overview of CYP systems with particular emphasis on their role as drug targets, their involvement in drug biosynthesis and potential strategies for developing new derivatives of drugs based on CYP engineering.
Our findings provide a strong rationale for developing new derivatives of this lead compound that could be used in combination with cetuximab in cancer patients to improve clinical outcomes.
The objective and motivation of this work is to develop new generalized type k-fractional derivatives, which are the generalized form of the existing fractional derivatives, as well as to highlight the importance of their applications in diverse research areas.
To develop new energetic materials, the eleven nitroester substitution derivatives of prismane were investigated at the B3LYP/6-311G** level of density functional theory (DFT).
To improve its therapeutic potential, new chitosan-sulfonamide derivatives have been designed to develop new wound dressing biomaterials.
In trying to develop new anticancer agents, a series of 1H-pyrazolo[3,4-b]pyridine derivatives was designed and synthesized.
A series of novel 1,2,4-triazole bearing 5-substituted biphenyl-2-sulfonamide biphenyl-2-sulfonamide biphenyl-2-sulfonamidederivatives angiotensin II subtype 2 (AT2) receptor agonists as novel antihypertensive candidates.
Alongside the erastin derivatives, these new molecules may help to develop new drugs that can inhibit this important transporter in a clinical setting.
