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This number was also sufficient to detect a reduction in hookworm prevalence of 30%.
Sample size was calculated based on a previous investigation [8] to detect a reduction in myocardial infarct size of about 50%.
With a two-sided alpha = 0.05 and 1-B = 0.80, comparing Arms A to B, the study was estimated to have the power to detect a reduction in cumulative virologic failure with a rate ratio of ≤0.74.
With this sample size, the study had 80% power using a 5% level of significance, to detect a reduction by one third in the incidence of clinical attacks of malaria in the treatment group.
This assay was able to detect a reduction in the extent of SNARE complex binding of Munc18-1 withethe mutation Y337L [33] in a domain that has recently been show to directly interact with SNARES [32].
The study was powered to detect a reduction in complication rates from 50% to 34%.
Inter-patient variation had no significant impact on power to detect a reduction in harm rates.
The study was powered to detect a reduction of 1.5 to 2.5 activities affected by back pain.
The present study was designed to detect a reduction in metabolic rate of about 30% in sheep.
Alternative explanations are that the current study was too short or underpowered to detect a reduction in exhaled nitric oxide.
For a condition with a lower prevalence of 15% (e.g. some respiratory conditions), having 80% power to detect a reduction of 5% would require a sample of 1450.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com