In this report, we use two small molecule inhibitors, PP242 (dual mTOR (mammalian target of rapamycin) kinase inhibitor) and hippuristanol (eIF4A inhibitor), to define IRES regulation via a Bcr-Abl-mTOR-eIF4A axis in CML cell lines and primary patient leukaemias.
"Others are trying to define this space via leaks, quotes to the media and public statements that are probably ahead of the president".
One of the goals of the current study was to develop a simple and sensitive method to define α-oxidation via precursor-to-product relationships and measure its rate versus the competitive β-oxidation step for GHB metabolism.
To define a contribution via its enzymatic activity, we mutated the catalytic site of group V sPLA2 to generate an enzymatically inactive protein (group V sPLA2-H48Q) (Lambeau & Gelb, 2008).
The fabrication processes of the NTG-LEDs were began to define the several n-contact vias by using an inductively couple plasma (ICP) to etch through the MQW to the n-GaN by an ICP etcher.
Although the vast majority of Americans continue to define the national character via real estate metaphors -- frontier, panorama, province -- Rapaille believes that we will ultimately accept his Freudian interpretation of our inner life.
We don't need a white-as-hell network to define what that means via the Emmys.
We don't need a white-as-hell networks to define what that means via the Emmys.
In spite of its effectiveness, the use of amiloride to define uptake of cargo via macropinocytosis [23] [29] has been recently criticized since amiloride also inhibits albumin uptake in kidney epithelial cells [38] [39] and alters the cellular pH in cultured cells [40].
Below, let us describe how to extract the useful information from the benchmark datasets SR and SK to define the peptide samples via (5).
In contrast to the two AAA+ ATPases that are present in many different multisubunit complexes (RUVBL1 and RUVBL2), PIH1D1 and RPAP3 are specific to the R2TP complex and are likely to define substrate binding, potentially via interaction with the tetratricopeptide repeats of RPAP3.
