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The study combined results from mathematical modelling of the care pathway, research evidence on effective interventions and findings from qualitative research with service users in a series of workshops to define, refine and select candidate service improvements.
There are many possibilities, and it'll be up to your creative muse to define, refine and act upon them as wished.
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Who will define, refine, confine, design?
For example, the 'James Lind Alliance' (JLA) priority setting partnerships – formal partnerships of patients, carers and healthcare professionals – generate, define, refine and prioritize unanswered research questions [ 15, 16].
After you start to connect these things, you have to define it, refine it, respect it and protect it.
There have been various attempts to define and refine it since the early 1980s, when a Mexican architect and conservationist called Héctor Ceballos-Lascuráin claims he coined the expression (although others have since disputed he was the first).
All sorts of informal "academies" – among others the Faber academy, the Mumsnet academy, and the Guardian's own creative writing masterclasses – have naturally risen in the wake of academic creative writing culture, but it is up to universities to steer that culture, to define and refine it as it evolves.
Indeed, Mr. Hamilton, having begun his career at a time when polls were essentially seen as little more than snapshots of the feelings of the broad electorate, helped make them strategic tools that allowed candidates to define and refine messages and pitch them to specific groups of voters.
As it turns out, she is an enormous help – as winner of a cynical postmodern talent show who's turned out to actually have talent even if it was not the talent she was on the show for, a certain sort of talent to define and refine the very image of who she is as a figment of the diminishing tabloid imagination – in helping me get my X Factor bearings.
That's why "focus groups should be used not to define but refine the product".
Equation 1 shows operations used to define or refine an IntentScope.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com