Sentence examples for to decrease the functionality of from inspiring English sources

A commonly-held assumption is that disease-associated mutations in the DNA binding region of transcription factors act primarily to decrease the functionality of the protein, thus altering the expression levels of their target genes.

The specific binding of the PH domain to PIP2 should, in principle, decrease the functionality of the accessible PIP2 at the plasma membrane.

These results seem to show that most AS events decrease the functionality of protein products.

These results suggest that CBA may reduce the ability of NMJ to transmit signals to SKM fibers thereby affecting the mobilization of intracellular calcium stores, which would decrease the functionality of muscle contractions and the ability of muscle satellite cells to successfully fuse to form new tissue in response to muscle injury.

By using multi-target drugs we can decrease the functionality of entire protein cascades, which explains how multi-target design can produce more effective results, while not influencing drastically any components within the system.

However, data suggest that other anti-cancer agents, including chemotherapy and targeted agents such as EGFR inhibitors, might also have effects to decrease the quantity or functionality of tumor vasculature [ 5- 10].

The gel time was found to decrease with increasing functionality of the system.

In fact, current theories trying to explain other impulse controls disorders such as compulsive drug taking postulate that in the transition from recreational drug use to addiction a decrease in the functionality of reward systems occurs prior to the instatement of compulsive drug-seeking behavior [9] [11].

The decreased stability of the truncated HBx mutants suggested that we had to overcome decreased protein levels of HBx mutants to test the functionality of the C-terminal truncated HBx mutants.

We assume that an increase or a decrease in the activity of a biochemical pathway is accompanied by a respective trend for increase or decrease in the functionality of most of the genes forming the pathway, whose fluctuations in expression affect the given pathways' state.

If there is no immediate intervention, additional damage occurs, with a decrease of the functionality of the hand.