CFP-10 differentiated DCs (CFP10-DCs) are phenotypically and morphologically similar to DCs differentiated conventionally with GM-CSF [20].
Am I just prone to DCS anyway?
Here we ask whether targeting of both adjuvant and antigen to DCs is sufficient to induce immunity.
Antigens targeted to DCs via the C-type lectin Langerin/CD207 are cross-presented to CD8 T cells in vivo.
Delivering antigen to DCs via surface receptors is thus an appealing strategy to evoke cellular immunity.
Microparticulate systems for delivery of therapeutics to DCs for immunotherapy have gained attention recently.
A cyclized synthetic peptide bearing the sequence CYTYQGKLC binds to DCs in a concentration-dependent manner.
Polyplex-formulations proved successful for delivery of RepRNA encoding influenza virus hemagglutinin and nucleocapsid to DCs.
Therefore, the access of dying tumor cells to DCs that are maturing to activated NKT cells efficiently induces long-lived adaptive resistance.
We show that DEC-specific mAbs deliver pdA dT to DCs for the efficient production of type I interferon in human monocyte-derived DCs and in mice.
Results showed that the synthesized E2-705 peptides binds to DCs by interaction with DC-SIGN receptor.
