And the initial designers of a regulatory structure would be unlikely to create the duplication and overlaps of jurisdiction that this defense supports although complex systems (think of a passenger jet airplane) often have duplication and redundancies deliberately embedded so as to provide backstopping for component failures (such as the regulatory problems just described).
It seems particularly unlikely that an essentially adjacent duplication of rps14 within the mitochondrial genome would have occurred in such a manner as to create a perfect duplication of the normal-length rps14 coding sequence without any trace of rpl5, which in virtually all angiosperms is separated by only 1 NT from the 5' end of rps14 (see below).
They know where the system breaks down, where it creates duplication, and how it can better meet needs.
The critics contend that the system creates duplication, including more top jobs like superintendent or police chief.
Although, in part, these new agencies have been established to streamline funding, the changing architecture of DAH has raised concerns that DAH is becoming increasingly fragmented (3– 5), potentially creating duplication and making the process of efficient resource allocation at the country level challenging (6, 7).
Within a few hours of Mr Giscard d'Estaing's announcement of his proposals, the commission had rushed out a statement denouncing them as liable to create "confusion and duplication of bureaucracies" and "unequal treatment of member states".The European Parliament, the third element of the EU's institutional triangle, also is unamused.
This PAC clone was used to create the MECP2 duplication mouse model and predict the human disease, and on a Mecp2 null background it rescues loss-of-function phenotypes (Collins et al., 2004).
Alternatively, rather than rearrangements being mediated by the duplications themselves, the inversions could have helped to create the complex segmental duplication architecture present at their breakpoints [ 43].
ISEcp1-mediated transposition was shown to create a 5-bp duplication of the target sequence TATGA (Fig. 2).
Interestingly, six SNORA25 paralogs have multiple poly(A) sequences, suggesting that some rhesus monkey SNORA25 sequences might have undergone several rounds of duplication, to create the variant paralogs.
