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Representations with an absolute time reference like posteriorgrams would be more prone to time-dependent variation, urging the use of time warping algorithms to compute the alignment between two time series.
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It applies IsoRank to compute the alignment score between each pair of networks, and then employs a PageRank-Nibble algorithm to cluster all the proteins by their alignment score (Liao et al., 2009).
Columns denote the scoring function (DALI, TM-Score, I-value) used to compute the alignment score.
In-house Perl scripts were used to compute the alignment statistics.
GDDA-BLAST utilizes rps-BLAST in NCBI BLAST 2.2.15 package to compute the alignments.
First, we discard all alignments or single genome regions that were used to compute the alignments for the current guide tree node.
Between 50 and 350 trajectory pairs were used to compute the average alignment (Table 1).
The number of homologous sites depends on the method used to compute the fixed alignment.
BALIGN can be used to compute the pairwise alignments for the given lists of sequences.
We used the program SSEARCH v36.3.5 from the FASTA package (fasta.bioch.virginia.edu/) (Pearson, 1996) to compute the optimal local alignment score between each human UCNE and each conserved fish genomic sequence.
We use the SSEARCH program from the FASTA v36 package [ 20] to compute the Smith-Waterman alignment score between all pairs of peptide sequences using default parameters optimized for high sensitivity (BLOSUM50 substitution matrix and E-value cutoff of 10).
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