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In order to clarify the implication of LOXL2 enzymatic activity in such processes we created two LOXL2 mutants affecting the conserved catalytic domain (Fig. 1A).
To clarify the implication of oxidative stress in the progression to osteoarthritis (OA) from the point of view of oxygen free radical-induced genomic instability, including telomere instability and resultant replicative senescence and dysfunction in human chondrocytes.
Although further work is required to clarify the implication of Cx in renal inflammation, the Cx hypothesis may be of interest in the recruitment of inflammatory cells in the kidney, as several studies showed an important role of these proteins in the inflammatory response.
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Plotinus often spoke of it in extremely negative language, but his object in doing so was to stress the inadequacy of all human ways of thinking and speaking to express this supreme reality or to clarify the implications of the claim that the Good is absolutely one and undetermined, the source of all defined and limited realities.
During the committee session May was asked to clarify the implications of the draft bill's wording for encryption.
It is possible to clarify the implications of changes in crater temperature with simultaneous observation of ground deformation.
"Our primary concern as church leaders has been to clarify the implications of the Social Welfare reforms passing through Westminster for the people of Northern Ireland," said Cardinal Brady.
We specifically wanted to clarify the implications of the identification of steatosis on an ultrasound report for the practicing clinician.
Prospective studies are needed to clarify the implications of this finding, but the observations suggest that smoking cessation in diabetes may lead to improvement in subjective well-being.
Second, it is necessary to clarify the implications of the current legal frameworks in African countries, or develop these where they are not existent or appropriate.
In such cases, explicit modelling of the drop-out process (e.g. Diggle & Kenward 38 and Little 39) might help to clarify the implications of drop-out for model validity.
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