Sentence examples for to circumvent tolerance from inspiring English sources

In order to circumvent tolerance problems after hematopoietic transfer, the speed congenic technology was used to generate mice with the same C57/BL6J genetic background for the two following strains: Prp0/0 prion deficient mice [1], and Tga20 mice [2] that were obtained from Pr. Charles Weissmann (Scripps Institute, Florida).

Using HLA-A2 transgenic mice and the allo-restricted strategy to circumvent tolerance to MDM2, we have previously demonstrated that CTL specific for an HLA-A2 presented peptide can kill a panel of human leukemia cell lines, while MDM2 expression levels in normal cells were too low to trigger CTL killing [26].

This finding may also in part account for the observed capability of AMD473 to circumvent adduct tolerance and DNA-repair mechanisms associated with resistance to cisplatin.

This strategy may provide a platform for the delivery various anti-cancer molecules to the tumor loci as well as for coating tumor cells to circumvent immune tolerance in order to generate therapeutic antitumor effects.

Effective vaccine strategies must circumvent tolerance.

To circumvent the immunological tolerance for mAQP4, we used AQP4-knockout mice (Acc. No. CDB0758K, ref. [ 37 ]) in E series as hosts, or used wild type mice in D series.

In this paper, we evaluate three different logic mapping algorithms with defect tolerance to circumvent clustered defective crosspoints in nanowire reconfigurable crossbar architectures.

The response of thalamic oscillators to external perturbation could potentially clarify the role of the thalamus in essential tremor (Smeal et al., 2010) and may provide insights into how tremor could be better controlled through DBS, in order to circumvent problems such as progressive tolerance to stimulation (Barbe et al., 2011).

A commission spokesman, treading carefully amid a row between two of the EU's core members, cautiously says that this manoeuvre appears to circumvent the law, and is "under investigation".On one level, the dispute is about risk tolerance.

Too many parked cars to circumvent.

Some have proposed reforms to circumvent paralysis.