In the majority of cases dislocation looping is the controlling mechanism, challenging the applicability of traditional continuum dislocation cutting models to the underaged Al Cu system at 0 K.
However, at such field strengths, the spatial non-uniformity of the Radio Frequency (RF) transmit profiles challenges the applicability of most MRI sequences, where the signal and contrast levels strongly depend on the flip angle (FA) homogeneity.
It has done so by placing dissuasive ads in Lebanese media, by challenging the applicability of international conventions on the regulation of refugees and, most recently, by passing a highly controversial and symbolic anti-immigration law.
The magnitude of the local TB burden, exacerbated by limited financial and human resources at public healthcare facility level, challenges the applicability and impedes the implementation of international guidelines.
The results challenge the general applicability of the oft-quoted two-degree-of-freedom model of 'mode-coupling', and also indicate some reasons for the difficulty encountered in validating models of friction-induced vibration.
Several recent findings challenge the general applicability of the homing cycle: in Naegleria, an apparently asexual amoeba, an intron with HE was reported to be of ancient origin, frequently lost in different lineages, but persisting as a functional enzyme in others [ 18].
In addition, the lack of standardization of scoring with different cut-off thresholds used to determine 9p loss represents a major challenge to the applicability of I-FISH in a clinical setting [ 42].
When reasoning about the decision model's applicability, one must also challenge the settings to which the decision model is applicable.
Carroll's Pyramid is probably the most popular and established CSR concept, having become accepted as a paradigm, but it can be criticised on the grounds that like much of the CSR literature, it was generated within the US and thus, its global applicability is open to challenge.
