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"to block off" is a correct and usable phrase in written English
You can use it to describe the action of preventing access to an area or making something inaccessible, for example, "The authorities blocked off the area to keep people from entering".
Exact(57)
They had managed to block off nearly every intersection in the main business district.
The city government has encouraged such barrios seguros, permitting residents to block off their streets.
The authorities' attempts to block off the political center of the city have provoked public ire.
-- to block off a room for monthly live performances of old-time radio plays.
The marines used concrete barriers to block off two roads leading to the city from Baghdad.
Except for two police vans used to block off traffic, the police were conspicuously absent.
Officers from the Territorial Support Group charged at rioters and attempted to block off side streets.
The cable companies, by demanding the right to control access, seemed to want to block off that frontier.
A barge was being sunk to block off a bayou, sending water out into marshland rather than into populated areas.
Similar(2)
An original primer design using properties of LNA allows to block off-target amplification.
In order to solve the problem of promoter leakage, we next screened for endogenous miRNAs that selectively express under normoxic condition to block off-target transgene expression.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com