RACK1 becomes translocated to the nucleus in association with the scaffolding protein 14-33zeta in response to cAMP signaling to promote chromatin remodelling that includes H4 histone acetylation resulting in BDNF transcription [ 4, 23].
In apoptotic cells, the membrane phospholipid phosphatidyl serine, which is normally found in the internal portion of the cell membrane, becomes translocated to the outer leaflet of the plasma membrane, thereby exposing phosphatidyl serine to the external environment.
During apoptosis, PS becomes translocated to the outer surface of the cell membrane, and Annexin V/PI assay detects the PS on the outer surface.
Another marker of platelet activation is CD62P, which is localised in resting platelets in intracellular granules and becomes translocated to the platelet surface upon platelet activation.
An earlier study had shown, however, that the novel PKC isoform PKCε becomes translocated in the calyx of Held nerve terminal upon phorbol ester stimulation (Saitoh et al., 2001).
Bridges were formed as neurites extended from a neuron in a groove, contacted adjacent plateaus, pulled the neuron up to become suspended over the groove, and the soma translocated to the plateau.
Similar to that seen with PKC δ, rhoA also translocates from the cytosolic compartment to become membrane-bound upon activation.
Next, to become a functional mitotic protein NuMA needs to be translocated from the cytoplasm to the mitotic centrosomes.
It has been shown that PKC δ translocates from the cytosolic compartment to become membrane-bound upon activation.
ATF6 is eventually translocated to the Golgi, where it is proteolytically processed to become an activated transcription factor that is involved in the upregulation of XBP1 mRNA and other UPR genes [10].
