Exact(4)
He et al. came to the similar conclusion that smaller particles were more likely to be uptake by non-phagocytic cells [23].
Faint and intermittent 99mTcO4 – uptakes along the abdominal wall were also observed in the same 12 mice, which were speculated to be uptake to the peritoneal dissemination of the cancer cells (Figure 3C).
For these non-targeted BSA-modified MNPs, intracellular distributions were the same, but the rod-like MNPs were more likely to be uptake by macrophages; furthermore, the BSA-modified MNPs gathered in RES-related organs soon after intravenous injection, but the rod-like ones were expelled from the lung more quickly and expelled from the spleen more slowly.
The mechanism for this reversal was postulated to be uptake from the surrounding media, thus providing a bypass to the metabolic DHFR node.
Similar(4)
The capacity for AuNPs to be uptaken by cells may allow improved delivery of antigens and therefore improve the overall vaccine antigen dose delivered to APCs.
Moreover, the trend observed in this dynamic uptake experiment also differs from that reported for uptake of similar PEG NPs by ECs in a static culture, where the smaller disks were found to be uptaken the most.
Due to the higher surface charge density at the tips, the rod-like gene complexes were prone to use the tips to contact with cell membrane, which facilitated to be uptaked by HepG2 cells.
Silver staining and transmission electron microscopy (TEM) further confirm that the Au DENPs are able to be uptaken by macrophages and are located dominantly in the lysosomes of the cells.
Related(1)
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