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Conversely, genes in starvation-repressed clusters are less likely (compared to all genes) to be maintained silent by this protein in cycling cells (these and other findings related to histone acetylation described below are summarized in Fig. 7 and Additional File 5).
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Furthermore transposable elements are maintained silent by epigenetic mechanisms in normal conditions (Feschotte et al. 2002).
The problem for deflationists who grasp the second horn of the dilemma is that they must admit that there is no way to complete this project: the deflationary theory of truth can only be maintained by remaining silent about the theory of meaning.
The high fecundity of marine bivalves together with an unpredictable and highly variable success of reproduction and recruitment (sweepstakes reproduction) might produce a greater decoupling between Ne and N than in other organisms with lower fecundities, and we suggest this could explain why a higher segregating load could be maintained for a given silent mutation effective size.
At the time of the study, some paediatric gastroenterologists thought that silent patients could be maintained on a normal diet if they were regularly followed.
In Minas Gerais, OROV has been maintained in silent cycles, probably because of inadequate epidemiologic conditions, such as the high density of Culicoides paraensis mosquitoes in urban areas, a limiting factor for an epidemic cycle deflagration.
They are maintained in a silent state through association of the nucleolar remodelling complex (NoRC) with the rDNA promoter in mammalian cells (Strohner et al, 2001; Santoro et al, 2002).
In stem cell chromatin, less accessible lineage-specific genes are maintained in a silent but transcriptionally available (poised) state, which is characterized by the simultaneous presence of both the repressive H3K27me3 and the activating H3K4me3, creating so-called bivalent domains (Fig. 3C).
Serosurveys of persons handling dromedary camels in this region could help to determine whether silent or unrecognized infections are being maintained in humans.
Though the silent state of var genes is maintained over many blood stage generations, it is critical to antigenic variation that each member can be re-activated.
In the attractor 1, as enumerated in Fig. 3a, A is highly expressed and B is silent, and this state is maintained through the positive and negative feedback loops (Fig. 3b, top).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com