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TEA appears to be less potent with respect to systemic toxicity and RT irritancy than DEA.
The reported PknB inhibitors were found to be less potent against whole cells as compared to the purified protein.
What kind of a stock market will investors encounter if the Fed's moves indeed prove to be less potent this year?
Previously, scientists exploring the shadowy world of designer pathogens found that superbugs made by genetic engineering often turned out to be less potent than their natural progenitors.
Under these conditions OA appears to be less potent than the other two fatty acids, while EPA and DHA effects are very similar to each other.
Nicotinamide is a known inhibitor for sirtuins, and it was found to be less potent inhibitor for SIRT6 than it is for SIRT1.
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A pure population of only one cell type, which could be easier to define, may be less potent and effective.
Compared to BI2536, it was less potent, but still had the ability to suppress DAPK activity partially (Supplementary information, Figure S1N), which could account for the observation of reduced DAPK/pS308 signals at high BI6727 doses (Supplementary information, Figure S1M).
Partial substitution of kava extract for CDP suggests that the herbal compound may share a mechanism of action similar to CDP, but is less potent.
Overall, similar observations were made for the other fatty acids studied, although compared to C22 6 they were less potent and/or less specific activators of PPARα, especially C18 1.
Wortamannin is a microbial secondary metabolite that can irreversibly inhibit PI3KCIII through covalent binding, whereas LY294002 is a morpholine derivate of quercetin binding to PI3KCIII, which is less potent than wortmannin (Supplementary Table S1).
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