Sentence examples for to be in close linkage from inspiring English sources

The -1082, -819 and -592 polymorphisms are shown to be in close linkage disequilibrium and construct only three haplotypes in the white population (GCC, ACC and ATA in an order of -1089/-819/-592) [ 16].

The EGF +61A/G polymorphism may be in close linkage with nearby causal variant in one ethnic population, but not in another.

ITS2 and 28S DNA sequences were aligned independently using MUSCLE [ 76] and then concatenated for all further analyses, as these two genes are assumed to be in close physical linkage.

Besides identifying a real causative polymorphism directly responsible for the phenotype, allelic association may point to a polymorphism that is in close linkage disequilibrium to the associated marker.

Of the SNPs showing significant or suggestive associations with the traits, several were homologous to genes of known immune function or were in close linkage to such genes.

This phenomenon may be due to an alternative hypothesis that HLA may only be a genetic marker, which is in close linkage with another NPC predisposition locus.

Thus, when the two QTLs were in close linkage, the distance between the two QTLs varied from 0.05 to 0.5 cM for the 60 K assay and from 0.004 to 0.5 cM for the 800 K assay.

The m2 mutations were in close linkage disequilibrium with the m1 mutations; 53% m1 mutants had the mutation in the m2 site.

Surprisingly, none of the sixteen candidate genes was in close linkage with the locus controlling the carbonaria-typical polymorphism.

The variant that we have used in this study is in close linkage disequilibrium (LD) with variation within a transcription factor binding site located 5' of CRP that is associated with circulating concentrations of CRP and thought to be functional.[43] [45] It is unlikely that this functional variant, or one in close LD with it, will have pleiotropic effects.

The studied genetic variants in the ABO gene fall into a major haplotype block and were in close linkage disequilibrium (D′ > 0.98).