The main cause for tiotropium's unfavourable cost-effectiveness ratio is a combination of a relative high price for tiotropium, a low number of hospitalisations without tiotropium treatment (on average 0.14/year) and a non-significant treatment effect (on average 0.94) with respect to avoiding exacerbation-related hospitalisations.
This is relatively low due to the combination of the following factors: a) a low number of hospitalisations without tiotropium treatment (on average 0.14/year), b) a non-significant treatment effect (on average 0.94) with respect to avoiding exacerbation-related hospitalisations, and c) the relatively short duration that this event influences QoL.
*It might be necessary to intubate because of conversion from negative intrathoracic pressure to positive pressure to avoid exacerbation.
Care should be taken to avoid exacerbation of pulmonary oedema and haemorrhage.
The trials were done before sedation on the initial visit, and always before orthopaedic examination to avoid exacerbation of lameness.
Management, rather than cure, involves routine work to avoid exacerbation events, detect and avoid recurrence, and to mitigate – and sometimes prevent – disease progression.
Additionally, treatment with BVZ can significantly alter a patient's treatment planning, as it can require treatment cessation to avoid exacerbation of an adverse event.
These results clearly demonstrate that, in order to avoid exacerbation of ascertainment bias and propagation of noise, network-based biological inference methods have to be supported by statistical models that take into account the degree distribution.
Primarily, is there an optimal dose of DNA and dosing regimen capable of provoking strong cellular and humoural responses to the antigens produced while avoiding exacerbation of pro-inflammatory responses to the vaccine and delivery vehicles utilised themselves.
On the one hand, groups may choose to cope with impairments using different coping strategies, e.g. by resting and avoiding exacerbation versus carrying on with tasks as usual.
The findings of this Phase II efficacy trial supported the use of a standalone community-based WBV intervention to improve functional performance of the lower limbs of people with COPD while avoiding exacerbations of the disease.
