Sentence examples for to avoid tolerance from inspiring English sources

We tested a new schedule of injections designed to avoid tolerance and to induce neurobiological changes relevant for depression.

To avoid tolerance, separate groups of animals were tested at 24, 48, and 72 h post-PNA treatment.

Thus, if this process is to be effectively manipulated in order to release the brake, we have to stimulate APCs with an antigen significantly different from "self" to recruit effector cells, balance cytokines to obtain a pro-inflammatory milieu, and finally, inhibit immune checkpoints to avoid tolerance.

Some doctors are sensitive enough to realize this, but, wanting to avoid tolerance and misuse, the responsible ones generally don't go around offering up refills out of the blue.

This titration schedule was advised in order to avoid tolerance effects.

The animals received seven inhalations during four weeks with increasing concentrations of OVA (1~5 mg/mL) in order to avoid tolerance.

However, oral delivery is challenging, requiring formulations to overcome the harsh gastrointestinal (GI) environment and avoid tolerance induction to achieve effective protection.

Although the proteolytically active allergen Der p1 can disrupt epithelial TJs to facilitate transport of allergen across the epithelium [ 58], it has been suggested that ADCs need a 'danger signal' to activate T-cells sufficiently and thus avoid tolerance [ 59].

On the other hand, impaired clearance of apoptotic cells in the bone marrow induces an increased stimulation of immature, self-reactive B cells that could undergo sustained receptor editing in the bone marrow or avoid tolerance.

In light of these observations, it seems important to ensure a maintained mature phenotype of the adoptively transferred CML-DC in order to avoid eventual tolerance induction.

In the "edicts of pacification," which Bodin believed were the best means to avoid war, temporary tolerance takes precedence while final peace is delayed until a time when "God will grant us the grace to unite the nation in the same fold".