Exact(6)
Great care should be taken to avoid dose errors when preparing drug dilutions.
Furthermore, gemcitabine was administered only once every two weeks, concurrent to irradiation to avoid dose reduction in radiotherapy.
To avoid dose calculations in a high uncertainty region a PTV-m consisting of the PTV excluding the "flash region" was used for dosimetric evaluation.
While a smaller volume insulin injection is a potentially attractive feature of U-500 insulin, it is critical to avoid dose confusion when switching from U-100 insulins or insulin analogs.
During the first 18 months of the trial, however, cyclophosphamide was replaced by 10 15 mg chlorambucil orally on days 1 8, and up to 18 months was allowed for the 12 courses to avoid dose reductions.
We propose that it may be better to start docetaxel capecitabine at a higher dose, with dose reductions as needed, rather than initiating therapy with lower doses to avoid dose reductions.
Similar(54)
Metronomic chemotherapy is the frequent administration of cytotoxic drugs at a low dose that is designed to avoid dose-limiting adverse effects that would require rest periods.
For most participants, the attempt to self-manage medication involved a constant struggle to balance their need for optimal pain relief against their wish to avoid dose-related side effects.
In general, data to date indicates that TDM may be required in about 30 to 40% of patients to avoid dose-dependent toxicity as well as therapeutic failure [ 24, 122].
Therefore, a schedule of continuous 5-day dosing on alternate weeks was deemed appropriate to try to avoid dosing interruptions.
It was important to avoid doses that would eliminate the activity or expression of cathepsin K because this could result in additional phenotypes not relevant to ML-II.
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