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Features typical of an acute injury like myocardial oedema, microvascular obstruction, and intramyocardial haemorrhage make the acute scar a much more complex entity to analyse compared with a chronic scar.
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Intention-to-treat analyses compared treatment groups using logistic regression for neonatal mortality and Cox regression for infant mortality.
Intention to treat analyses compared incremental costs with incremental ulcer-free days (cost effectiveness analysis) and incremental quality adjusted life years (cost utility analysis).
In addition to diseaserelated cost analyses compared to a control group including age group comparisons, comorbidities, the proportion of multimodal treatment and medication treatment patterns were described.
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METHODS: Intent-to-treat (ITT) analyses compared treatment arms by randomized pacing mode.
In intention-to-treat analyses comparing groups 1, 2 and 3, baseline covariates were gender, age, term and university.
Time-to-event analyses comparing the high-exposure group with the standard-exposure group were performed using Kaplan Meier plots and Cox proportional hazards models.
First, we assessed the effect of adding new data to meta-analyses, comparing results in 2000 with the results in 1994.
We subjected any imputation of missing data for the primary outcomes to sensitivity analyses; any substantial difference in the imputed ITT analyses compared to available data analyses was incorporated in the interpretation of the study findings and the discussion.
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