Sentence examples for to affect internalization of from inspiring English sources
To address whether altered endocytosis causes lateral mis-localization of KNOLLE, we examined its subcellular distribution after interference with ARF1 function by a dominant-negative approach, earlier reported to affect internalization of the endocytic tracer FM4-64 (Xu and Scheres, 2005).
In hippocampal neurons, KIBRA has been shown to be involved in the suppression of AMPA receptor trafficking to the cell surface; the knockdown of KIBRA did not affect internalization of the GluR2 subunit of AMPA receptor, but accelerated the recycling speed to the cell surface (Fig. 2B).
Fourteen hit compounds affected internalization of Grb2, an adaptor responsive to EGFR activation.
Confocal imaging of HEK.hIP cells over-expressing the GFP-tagged Rab5a demonstrated that there was rapid co-localization of the hIP to Rab5a positive vesicles at or just below the cell surface indicating that Rab5a affects internalization of the hIP at an early stage.
The cell state (static or dynamic) does not affect cell viability upon interaction with the NPs but affects internalization of the NPs (cells in the dynamic state absorb the NPs more readily).
Ligand density is known to affect cell internalization of recognized substrates, 29) and variations in QD valency can affect cross-linking of surface proteins, activating signaling pathways and reducing receptor mobility.
This did not affect internalization and viability of an immortalized human lung epithelial cell line BEAS-2B.
Only cells with similar IR-B-SYFP expression levels (estimated by the VFP intensity signal) were considered since high expression levels of IR affect internalization rates (data not shown).
N-SYN was also effectively directed to the intracellular space of DA neurons, indicating that nitration also does not affect internalization in vivo (Figure 7).
Ligand modification affects internalization; obviously, loss of affinity cancels specific uptake mechanism.
This study indicates that NPC1 plays an important role in regulating endocytic mechanisms affecting internalization and efficacy of certain nanoparticles.
