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In order to address the function of exported proteins we used a gene knockout strategy combined with functional assays.
To address the function of BA1544, we performed structural and biochemical studies, which revealed that BA1544 is a MazG protein.
To address the function of the UCR and its YY1-motif in an in vivo model of MLV host interactions we introduced six consecutive triple basepair mutations into this region of the potent T-lymphomagenic SL3-3 MLV.
"This is a useful step forward in trying to address the function of olfactory receptors in sperm," says Gordon Shepherd, a neuroscientist at Yale University.
To address the function of IL-25 in tumor progression and metastasis, MMTV-PyMT mice were treated with an anti-IL-25 antibody or control antibody (Rat IgG) at the onset time of primary tumors (~4 5 week of age).
To address the function of Dkk1 in midbrain development we examined Dkk1+/− and Dkk1−/− embryos.
To address the function of septins in U. maydis, a deletion analysis was carried out.
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Cell biological studies designed to address the functions of these ADAMs in shedding of HB-EGF uncovered a contribution of ADAM19 to this process, but this was only evident in the absence of the major HB-EGF sheddase, ADAM17.
To address the functions of BAZ1B in the germline, we generated germline-specific conditional-knockout mutants of Baz1b (Baz1bcKO).
To address the functions of hMsd1, we depleted hMsd1 using siRNA oligonucleotides in HeLa and U2OS cells (Fig 2A).
To address the functions of the RAS in human glioblastoma, we first evaluated the effect of inhibiting renin and ACE in glioblastoma cells.
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