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The first observation we make, is that the RdRP model and the two antisense variants produce results in similar orders of magnitude, both with respect to active against silenced TEs, and active TEs against VLPs.
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New TB drugs are required to be active against both replicating and nonreplicating bacteria, and to penetrate tissues and granulomas to allow a reduced treatment duration [ 4].
In one of our studies the objective of the Agent is to generate molecules that are predicted to be active against a biological target.
Hundreds of drugs approved for something have been reported to be active against unrelated diseases – and sometimes approved to treat them.
For patients with polymicrobial infection the initial antimicrobial regimen had to be active against all identified pathogens in order to be classified as appropriate.
The new analogues in addition to being active against Gram-negative bacteria, possess activity against all tested Gram-positive bacteria.
Dalbavancin has been reported to be active against VISA, but shows poor activity versus VRSA [ 92- 94].
In a recent in vitro study, razupenem was found to be active against ESBL-producers, but its activity was significantly reduced by AmpC enzymes and carbapenemases [ 54].
Paclitaxol was conjugated to PLA PEG with an ester bond, the conjugate was found to be active against H7402 liver cancer cell line.
NER is known to be active against a range of bulky DNA lesions in addition to its main role in the repair of UV-induced DNA damage.
In order to provide a guide for whether a proposed compound is likely to be active against any of these targets, a simple modified Bayesian approach is used.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com