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In addition to activating the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt) pathway (Figure 1), phosphotyrosines also serve as docking sites for signal transducer and activators of transcription (STATs), such as STAT5.
In addition to activating the mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K), and protein kinase B (Akt) pathway, phosphotyrosines also serve as docking sites for signal transducer and activators of transcription (STATs), such as STAT5.
Although α-MSH may activate the phospholipase C signalling pathway (resulting in increased inositol phosphates, intracellular calcium and activation of protein kinase C) in addition to activating the adenylate cyclase cAMP signalling pathway, the overwhelming evidence from the literature (as reviewed in Eberle, 1988) points to the majority of the actions of α-MSH being mediated by cAMP.
We show here that, in addition to activating the canonical Wnt/β-catenin pathway, Wnt1 transactivates EGFR and stimulates ERK1/2 activity in many human breast cancer cells.
To stop a rout, the European Union must commit to activating the bailout.
The Eurogroup is supposed to draw up rules for such direct recapitalisation by June, with a view to activating the process next year.
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Time to activate the PODs.
I reached up to activate the roof.
Scientists have begun to activate the lander's drill.
Ms. Fleming had to activate the electronic keyboard while singing.
You then use this to activate the service.
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