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These MSCs are also able to activate further immunological cascades, including a variety of bone morphogenetic proteins (BMPs), that enhance and activate bone growth in the periphery [13].
They have the potential to activate further stress responsive mechanisms to re-establish cell homeostasis, to protect, as well as repair proteins and membranes [ 52].
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Tyrosine phosphorylated IRS1 then recruits downstream effector molecules which in turn activate further downstream signalling pathways.
Over-expression of the membrane signal transducers can activate further down-stream cascades.
Those factors can both activate further platelets and mediate a range of responses in other cells.
This interaction results in the recruitment of the adaptor molecules MyD88 and TRIF, which activate further downstream signaling cascades.
It is likely that DS-SILY20 is able to block SMC stimulation by sequestering PDGF or IFN-γ, thus, limiting the stimuli's ability to activate or further promote restenotic SMC behavior in either injured and healthy SMC phenotypes.
When PEDF binds to the receptors, it causes these complexes to disassemble and this activates further downstream signaling events inside the cell.
The presence of activated pericytes in dcSSc skin and the capability of these cells to transition into myofibroblasts when activated further support their likely contribution to dermal fibrosis in SSc.
In a screening setting, the index test activates further assessments to ascertain the occurrence of the studied lesion; so we did not count it among the negative ones and we used it to define the time of exit from the cohort.
The dural afferents might be activated further during dural exposure to inflammatory substances or when the dural mast cells are degranulated [5].
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