Zyman: It is a panacea … it utilizes existing assets to develop high-risk propositions before you see whether you can develop ways of activating better your existing business.
Furthermore, it is known that some IgG subtypes (in the form of immune complexes) are able to activate complement better than others.
If the new candidate promoter is also activated better in the diaphragm, it may be applicable for gene or cell therapies targeting this muscle; although, an entire, body-wide therapeutic gene expression might be the best choice for DMD patients, if we could achieve it without safety problems.
In the study of drotrecogin alfa (activated), better outcomes were observed in higher severity subgroups defined by APACHE II scoring and in lower severity subgroups defined by biologic markers of disease severity (i.e. IL-6 level and prothrombin time) [ 24].
Our use of 8-Br-cAMP to activate the endogenous PKA better resembles agonist-dependent activation [32], suggesting that perfused fibers should demonstrate a larger change in TnI versus MYBP-C phosphorylation, as observed (Figs. 6,7).
It is better to activate the lobby air supply system and meanwhile close the platform air supply system.
The largely represented CD1apos DDC subset was revealed to activate CD8+ T cells better than CD14pos DC but less efficiently than LC.
These studies raised a question: which is a better strategy, to activate or to inhibit ATM activity, in treating HCC patients?
Therefore, carriers not only activate mitochondrial biogenesis better than LHON affected individuals, but display also a better capability to activate the antioxidant machinery.
Women were better able to activate their stabilizing trunk muscles than men; but it is also possible that men, having a much higher degree of strength on maximal contraction, only need to activate a smaller amount of that maximum to perform a similar activity.
Different works have demonstrated that the maturation stage of DC that produce Dex have a critical impact on the Dex composition leading to a better capacity to activate T and NK cells [52], [74] [76].
