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Thanks to its broad spectrum of action, it is possible to select the specific wavelength to act selectively on the melanin pigment of seborrheic keratosis.
Moreover, none of the agents used to date are designed to act selectively upon the heart.
However, there is no apparent preference for PUMs to act selectively on positive or negative regulators of angiogenesis.
Figure 1A,B illustrates the time course of the endogenous GABA release evoked by a 90 s pulse of choline (Ch) or 5-Iodo-A-85380 dihydrochloride (5IA85380) reported to act selectively on α7 and on α4β2 nAChR subtypes, respectively.
Digitonin can effectively preserve p120 binding in some cell types, but appears to act selectively on soluble (as opposed to cytoskeleton tethered) complexes [4], [9] and previous attempts using TAP methods have been unsuccessful due to extremely low recovery of p120 complexes (unpublished observations).
The anabolic growth factor FGF18 appears to act selectively through FGFR3 to activate distinct downstream pathways in human articular chondrocytes.
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HDACis are reported to cause acetylated histones to accumulate in tumors (including neuroblastoma cells) as well as in normal tissues (including post-mitotic neurons), but often act selectively to inhibit cell growth of tumors at levels that have little to no toxicity for normal cells.
Interestingly, if there are strong inhibitory inputs acting on the motor cortex contralateral to the missing limb, these inputs act selectively on muscles within the stump, as the more proximal biceps representation showed no asymmetry in the two agenesic subjects whereas in the other two subjects it appears to have undergone a disinhibition similar to that observed after traumatic amputation.
To determine whether inhibitors of purine biosynthesis might act selectively against MTAP-negative tumors, two multi-center Phase I/II clinical trials of L-alanosine were started, but both trials were suspended early [16], [17].
Because of the clinical side effects and shortcomings of the previous list of therapeutic medications, new agents that act selectively on sensory pathways afferent to the limbic system by decreasing the secretion of neurotransmitters could be more selective in conditioned responses without concurrent sedation and hypnosis.
Multiple targets have been identified for Rho proteins (Jaffe and Hall, 2005) but it is not clear whether the isoforms act selectively through different or common downstream targets to mediate specific responses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com