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Selfing rates, averaged over mosquitoes was estimated as 0.44 with confidence limits, adjusted to account for the chance that an oocyst was selfed purely by chance of 0.31 0.56.
Would we still find a rarity effect if we analyzed the data with previously used methods (Document S3)? Compared to Barclay [9], our method differs in three aspects the accuracy rates to test the hypotheses on, the chance level for which to account the accuracy rates, and the way how to account for the chance level.
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To reduce possible impacts of publication bias in the study, we did not use original significance level for genes in association studies; instead, we defined a scoring system ranging from 0 4 in an attempt to account for the lower chance of publishing negative findings.
As the previous NSWPHS samples came from a single frame the weighting did not need to account for the differing chances of selection by type of phone use.
In order to account for the calculation of chance we used the kappa value [ 22].
To account for the frequency of chance associations between the NR and LacO array, an additional cross between LacO, GFP-LacI; HS > GAL4 UAS > Cap-H2 and a control line was tested.
To account for the possibility of a chance finding, we also compared the impact of poly-carbonate bottle use on several phenols not thought to be associated with polycarbonate bottle use.
Some also argue that ID goes beyond the available evidence and that it systematically underestimates the ability of non-intelligent, natural causes (plus chance) to account for the relevant biological complexity.
Survey-specific weights were used for all country surveys to account for the degree to which a woman's chances of being selected for the sample depended on household size and other DHS sampling criteria.
As a sensitivity analysis, all treatment comparisons for primary and secondary outcomes will also be presented adjusted for age at presentation to account for any chance imbalance between the treatment groups with respect to this potentially confounding factor using linear and logistic regression models for continuous and binary outcomes respectively.
To account for chance associations from multiple comparisons, we estimated the false-positive report probability (FPRP) for statistically significant gene environment interaction findings using a modified method described by Wacholder et al. (2004), originally introduced in molecular/genetic epidemiology and now widely accepted in that literature.
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