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To account for testing multiple contexts, the P-values are adjusted using the Bonferroni correction.
Of the studies that used commercial kits, 12 did not perform any modifications to account for testing a different species.
The α value for significance was adjusted to account for testing multiple visitor center cities (p = 0.05/14 visitor center cities = 0.0036).
No additional correction was applied to the gene-based score to account for testing the three models because of high correlation between the tests.
To account for testing differential expression across multiple genes, we adjusted p-values using the Benjamini and Hochberg approach for controlling the false-discovery rate (FDR).
The expression of TNF-α and MMP-10 correlated weakly with TB progression, and was not significant for multiple parameter testing (p = 0.0057 and 0.0066, respectively; to account for testing of 12 parameters, p-value of 0.003 was considered significant).
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It was possible to account for test arrangement artifacts, such as thermal dilation, to get a measure of pure autogenous shrinkage.
The reduction is to account for test variations and also to assure that line approaches a lower bound for experimental values, therefore, somewhat conservative.
To account for test variability over time, we derived an adjustment factor from the pooled short term fluctuation.
We used P < 0.05 as level of significance for testing of main effects and P < 0.01 for post hoc tests to account for multiple testing.
We calculated ' P values adjusted for correlated tests (PACT)' to account for multiple testing within a gene.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com