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This leads to a reduced level of reliability of bioengineering projects in terms of pre-determined factors of safety.
Concerning the mechanisms of action, a reduction in mechanical stress seems to contribute to a reduced level of myocardial apoptosis after cardiomyoplasty.
Mx2 restricts HIV-1 infection at a relatively late post-entry phase (Goujon et al., 2013; Kane et al., 2013) and leads to a reduced level of integrated viral DNA (Liu et al., 2013).
The association of several HATs was abolished at the rRNA gene in WSTF KD cells, correlated to a reduced level of H3K9-Ac.
In addition our results suggest that an overall reduction of MET1 levels in met1-3/+ plants could lead to a reduced level of DNA methylation activity prior to meiosis and promote seed size increase.
The chromatin remodelling complex B-WICH, which comprises the William syndrome transcription factor (WSTF), SNF2h, and nuclear myosin 1 (NM1), is involved in regulating rDNA transcription, and SiRNA silencing of WSTF leads to a reduced level of 45S pre-rRNA.
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It comes at the expense of transparency, so we must choose to operate at a reduced level of complexity and theoretical financial efficiency.
Replacing the 15 nt ITR5 spacer with that of ITR2 resulted in an ITR which Rep5 retained the ability to replicate at a reduced level (ITR5 3nt, Fig. 3D).
In this third screening, approximately 50% of subjects had continued to smoke at a reduced level, 25% had quit smoking, and 25% had resumed heavy smoking.
Low pHi in the presence of hyperthermia enabled cell respiration to continue at a reduced level with no further change in glycolysis.
Of note, we observe the binding of activators and p300 to H1-chromatin, albeit at a reduced level relative to chromatin depleted of H1 (see Fig. 4c).
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