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We had reported differences in cell cycle progression in pre- and post-senescence MSC and TMC, including more rapid cell division in TMC [6].
By comparison, the hydrophobic liquid poly(dimethylsiloxane) had little effect on TMC 120 release parameters.
TMC 120 release profiles and the mechanical properties of rings could be modified by the physicochemical nature of hydrophobic and hydrophilic excipients incorporated into the IVRs.
A hydrophilic excipient, lactose, had the surprising effect of decreasing TMC 120 burst release while increasing the apparent steady-state daily release in a concentration-dependent manner.
TMC 120 (Dapivirine) is a potent non-nucleoside reverse transcriptase inhibitor that is presently being developed as a vaginal HIV microbicide.
The TMC2, TEA and TEA × CSA were recognized as most effective terms on membrane flux and the most effective terms on rejection are the MPD × TMC, CSA2, TMC2 and MPD.
The activity of Pt co-catalyzed with Ru TMC 15 decreased with time suggesting that the macrocycle was desorbing from the supported catalyst surface.
The results demonstrate that TMC 120 is released in zero-order fashion from the rings over a 28-day period and that release parameters could be modified by the inclusion of release-modifying excipients in the IVR.
To avoid such non-specific interactions, Varkouhi et al. in 2010 introduced thiol groups in trimethyl chitosan (TMC) [45].
In TMC, p16 mRNA and protein were entirely absent, and the Ink4a/Arf locus had been deleted.
p16 protein is downregulated in post-senescence MSC, and absent in TMC [6], concurring with these results.
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