Sentence examples for tk can from inspiring English sources

Tk can be used as needed to develop user interfaces.

Use of TK can help to ensure studies are designed to be of most relevance to assessing potential risk in humans, and avoid the use of excessively high doses that could result in unnecessary suffering in experimental animals.

To help promote increased consideration of the important role TK can play in chemical risk assessment, we have gathered practical examples from the peer-reviewed literature, as well as in-house industry data, that highlight opportunities for the use of TK in the selection of dose levels.

Delivery of inhibitors to NF-кB combined with immunogene therapy using Flt3L and thymidine kinase (TK) can suppress Foxp3+ Tregs and product Th1 cytokines in the tumor microenvironment [ 89].

These basic studies have demonstrated that TK can reduce elevated blood pressure and inhibit remodeling in the heart and arteries [ 12, 13]; attenuate ischemic stroke in an animal model [ 14]; reduce the rate of smooth muscle cell proliferation [ 15], atherosclerosis, and apoptosis [ 16]; protect against ischemia/reperfusion damage [ 17]; and enhance angiogenesis [ 18].

However, mutation of HSV-TK or VZV-TK can cause resistance to acyclovir.

The expression of HSV1-tk can be imaged and monitored using specific radiolabeled substrates that are selectively phosphorylated by HSV1-tk and trapped within transfected cells.

Recent research has shown that HSV-TK can enhance sensitivity of radiation [ 10].

Consequently, the SFI-Tk can be recommended for clinical and research purposes in Turkish language populations.

HSV-TK can convert the prodrug ganciclovir into toxic nucleotide analogues that disrupt DNA synthesis in genetically targeted GPT progenitors.

HSV-TK can phosphorylate the nontoxic prodrug ganciclovir into ganciclovir triphosphate, which causes chain termination and single-strand breaks upon incorporation into DNA [ 82].