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Since the two viruses could not be cultured in a higher titre, it could not be determined whether the dynamic range is wider.
To demonstrate at least a 4 log10 reduction in virus titre, it is necessary for test mixtures containing low virus titres to undergo detoxification by molecular sieving, or to use a more sensitive assay such as LVP [ 8].
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Despite the fact that not every infection results in increased antibody titres, it might be expected that assay-measured increases in effective antibody concentration are considerably less biased than symptom-based definitions such as ILI.
This distribution of cases in age groups is of special interest in the light of HI serological results (see figures 8 and 9): regardless of the antibody titre considered, it appears clear that the prevalence of antibodies to H1N1sw is low under the age of 30.
A similar age-dependent fluctuation of prevalence was observed for all HI titres, but it should be noted that the prevalence of titres ≥1/160 remains globally modest at all ages.
In two flocks in Bavaria, all six TBEV antibody-positive horses which were re-tested after nine months had VNT-positive titres and it was also possible to detect TBEV in ticks collected in the vicinity of the stables [ 4].
From the Ab titre distribution curve, it was noted that RSV-specific matAb declined log linearly over the first six months of life.
The appropriate cut-off titre that differentiates it from a past cleared infection is debated; currently proposed cut-offs are 1 1,024 or 1 1,600 [ 6, 9].
The presence of tetherin had no effect on WT 89.6 virus titre however, as expected, it was able to reduce the titre of 89.6Δvpu at least 100-fold.
Although the original correlate of protection was defined in terms of hSBA titres [ 20], it was previously suggested that hSBA assays may have reduced sensitivity and that while hSBA titres ≥1 4 are predictive of protection, hSBA titres <1 4 may not necessarily predict susceptibility [ 8, 21, 28].
This inability to determine the true cause of the positive result can lead to serious consequences when counselling a patient with low titres levels – as it may increase her risk of abuse and abandonment.
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