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The titration phase was 2 weeks.
These side effects were most likely related to starting with a single large dose without any titration phase.
The most common adverse events were mild to moderate dizziness and somnolence, most of which were transient and occurred during the titration phase.
During this titration phase, glimepiride is discontinued.
A 12-week maintenance period followed the titration phase.
A total of 258 consecutive patients entered the titration phase.
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A 2-week washout period was followed by a 4-week dose-titration phase during which patients received lanthanum carbonate titrated up to 2250 mg/day.
After up-titration phase, patients received ivabradine or bisoprolol for another month.
Patients received a mean of 9.3 doses of FBSF during the dose-titration phase.
During the dose-titration phase, 34 patients (87%) experienced at least one adverse event.
After CFVR assessment, patients were randomized to ivabradine or bisoprolol and entered an up-titration phase, and CFVR was assessed again 1 month after the end of the up-titration phase.
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